The National Institutes of Health have designated sexual and gender minorities (SGM), also known as lesbian, gay, bisexual, transgender, queer, Two-Spirit, intersex, and other people who do not “fit” within the traditional heteronormative binaries as health disparate populations. SGM experience significantly higher rates of mood, anxiety, and behavioral/substance use disorders, suicidality among other mental health issues. Emerging evidence indicates that SGM also have significantly higher rates of some chronic health conditions, such as cardiovascular disease, hypertension, and diabetes. In this presentation Dr. Hoy-Ellis will share how past and ongoing marginalization, exclusion, and discrimination are the ‘causes of the causes’ of these health conditions through the framework of the Health Equity Promotion Model. He will also offer key strategies for providing culturally sensitive, effective services for SGM, from adolescence through older adulthood.